| 1555-1589 | Christophe Plantin. |
| 1589-1610 | Jan I Moretus (Plantin's son-in-law). |
| 1610-1614 | Balthasar I and Jan II (sons of Jan I). In partnership with Martina Plantin. |
| 1614-1618 | Balthasar I and Jan II Moretus. |
| 1618-1628 | Balthasar I, with Jan van Meurs as his associate. In partnership with Maria de Sweert (Jan II's widow). |
| 1628-1641 | Balthasar I. In partnership with Maria de Sweert. |
| 1641-1655 | Balthasar II Moretus (son of Jan II, nephew of Balthasar I). In partnership with his mother Maria de Sweert. |
| 1655-1674 | Balthasar II Moretus. |
| 1674-1681 | Anna Goos, Balthasar II's widow, with her son Balthasar III Moretus. |
| 1681-1696 | Balthasar III Moretus. |
| 1696-1707 | Anna Maria de Neuf, Balthasar III's widow. |
| 1707-1714 | Anna Maria de Neuf with her son Balthasar IV. |
| 1714-1716 | Balthasar IV Moretus. |
| 1716-1730 | Balthasar IV Moretus with his brother Joannes Jacobus. |
| 1730-1757 | Joannes Jacobus Moretus. |
| 1757-1768 | Franciscus Joannes Moretus (son of Joannes Jacobus). |
| 1768-1797 | Maria Theresia Borrekens (widow of Franciscus Joannes). |
| 1797-1805 | The five sons of Franciscus Joannes Moretus and Maria Theresia Borrekens, with Jacob Paul Moretus as manager. |
| 1805-1808 | Jacob Paul, Frans Jozef, and Lodewijk Frans Moretus, with Jacob Paul as manager. |
| 1808-1814 | Frans Jozef and Lodewijk Frans Moretus, with Frans Jozef as manager. |
| 1814-1820 | Lodewijk Frans Moretus. |
| 1820-1865 | Albert Moretus (nephew of Lodewijk Frans, son of Jozef Hyacinthus). |
| 1865-1876 | Edward Moretus (Albert's brother). |